Cognitive and neurological research
Dihexa
Also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408
A small molecule derived from angiotensin IV, studied for its effect on synapse formation in preclinical models.
What it is
Dihexa is a small molecule developed from angiotensin IV, a fragment of the angiotensin peptide system better known for blood pressure regulation. It was designed at Washington State University to be stable and to cross the blood-brain barrier, and research interest centres on its interaction with hepatocyte growth factor signalling.
What published research examines
- Hepatocyte growth factor and c-Met receptor signalling
- Synaptogenesis, the formation of new synaptic connections
- Spatial learning and memory tasks in rodent models
- Potency relative to other neurotrophic compounds in cell assays
Where the research stands
Dihexa research is preclinical and concentrated in a small number of laboratories. It has not been studied in humans.