Cellular and metabolic research
SS-31
Also known as Elamipretide, MTP-131
A mitochondria-targeting tetrapeptide that binds cardiolipin, and one of the more clinically advanced compounds in this catalogue.
What it is
SS-31 is a four-amino-acid peptide designed to concentrate in the inner mitochondrial membrane, where it binds cardiolipin, a phospholipid essential to mitochondrial structure and energy production. Its selectivity for that target is what distinguishes it from broader antioxidant approaches.
What published research examines
- Cardiolipin binding and inner mitochondrial membrane structure
- Electron transport chain efficiency
- Cardiac and skeletal muscle function in preclinical models
- Primary mitochondrial disease, where it has been through clinical trials
Where the research stands
SS-31, under the name elamipretide, has progressed further into human clinical trials than most peptides in this catalogue, with mixed results across indications.